Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA.
New Phytol. 2022 Aug;235(3):1057-1069. doi: 10.1111/nph.18156. Epub 2022 Apr 28.
Polycomb dictates developmental programs in higher eukaryotes, including flowering plants. A phytohormone, abscisic acid (ABA), plays a pivotal role in seed and seedling development and mediates responses to multiple environmental stresses, such as salinity and drought. In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana. vil1 mutants exhibit hypersensitivity to ABA during early seed germination and show enhanced drought tolerance. Our study revealed that the ABA signaling pathway utilizes a facultative component of the chromatin remodeling complex to demarcate the level of expression of ABA-responsive genes.
多梳抑制复合物在高等真核生物（包括开花植物）中决定发育程序。植物激素脱落酸（ABA）在种子和幼苗发育中发挥关键作用，并介导对多种环境胁迫（如盐度和干旱）的响应。在这项研究中，我们表明 ABA 通过 VIN3-LIKE1/VERNALIZATION 5（VIL1/VRN5）影响 Polycomb 抑制复合物 2（PRC2）介导的组蛋白 H3 赖氨酸 27 三甲基化（H3K27me3），从而精细调控拟南芥中 ABA 不敏感 3（ABI3）和 ABA 不敏感 4（ABI4）的适时抑制。vil1 突变体在早期种子萌发过程中对 ABA 表现出超敏反应，并表现出增强的耐旱性。我们的研究表明，ABA 信号通路利用染色质重塑复合物的一个可有可无的组成部分来划定 ABA 响应基因的表达水平。
