Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Cell Rep. 2024 Sep 24;43(9):114758. doi: 10.1016/j.celrep.2024.114758. Epub 2024 Sep 11.
Ethylene signaling has been indicated as a potential positive regulator of plant warm ambient temperature response, but its underlying molecular mechanisms are largely unknown. Here, we show that LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes. We found that the presence of warm ambient temperature activates ethylene signaling through EIN2 and EIN3, leading to an interaction between LHP1 and accumulated EIN2-C to co-regulate a subset of LHP1-bound genes marked by H3K27me3 and H3K4me3 bivalency. Furthermore, we demonstrate that INO80 is recruited to bivalent genes by interacting with EIN2-C and EIN3, promoting H3K4me3 enrichment and facilitating transcriptional activation in response to a warm ambient temperature. Together, our findings illustrate a mechanism wherein ethylene signaling orchestrates LHP1 and INO80 to regulate warm ambient temperature response by activating specific bivalent genes in Arabidopsis.
乙烯信号被认为是植物对温暖环境温度响应的潜在正向调节剂，但其中的分子机制在很大程度上尚不清楚。在这里，我们表明 LHP1 和 INO80 通过激活特定的二价基因与乙烯信号合作，以响应温暖的环境温度。我们发现，温暖环境温度的存在通过 EIN2 和 EIN3 激活乙烯信号，导致 LHP1 与积累的 EIN2-C 之间的相互作用，共同调节由 H3K27me3 和 H3K4me3 二价标记的一组 LHP1 结合基因。此外，我们证明 INO80 通过与 EIN2-C 和 EIN3 相互作用被募集到二价基因上，促进 H3K4me3 的富集，并促进转录激活以响应温暖的环境温度。总之，我们的研究结果说明了一种机制，其中乙烯信号通过激活拟南芥中特定的二价基因来协调 LHP1 和 INO80 以调节对温暖环境温度的响应。
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