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用于在X线片上识别退行性椎管狭窄导致的颈髓压迫的深度学习算法

Deep Learning Algorithm for Identifying Cervical Cord Compression Due to Degenerative Canal Stenosis on Radiography.

作者信息

Tamai Koji, Terai Hidetomi, Hoshino Masatoshi, Tabuchi Hitoshi, Kato Minori, Toyoda Hiromitsu, Suzuki Akinobu, Takahashi Shinji, Yabu Akito, Sawada Yuta, Iwamae Masayoshi, Oka Makoto, Nakaniwa Kazunori, Okada Mitsuhiro, Nakamura Hiroaki

机构信息

Department of Orthopedics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.

Department of Technology and Design Thinking for Medicine, Hiroshima University, Hiroshima, Japan.

出版信息

Spine (Phila Pa 1976). 2023 Apr 15;48(8):519-525. doi: 10.1097/BRS.0000000000004595. Epub 2023 Feb 10.

Abstract

STUDY DESIGN

Cross-sectional study.

OBJECTIVE

Validate the diagnostic accuracy of a deep-learning algorithm for cervical cord compression due to degenerative canal stenosis on radiography.

SUMMARY OF BACKGROUND DATA

The diagnosis of degenerative cervical myelopathy is often delayed, resulting in improper management. Screening tools for suspected degenerative cervical myelopathy would help identify patients who require detailed physical evaluation.

MATERIALS AND METHODS

Data from 240 patients (120 with cervical stenosis on magnetic resonance imaging and 120 age and sex-matched controls) were randomly divided into training (n = 198) and test (n = 42) data sets. The deep-learning algorithm, designed to identify the suspected stenosis level on radiography, was constructed using a convolutional neural network model called EfficientNetB2, and radiography and magnetic resonance imaging data from the training data set. The accuracy and area under the curve of the receiver operating characteristic curve were calculated for the independent test data set. Finally, the number of correct diagnoses was compared between the algorithm and 10 physicians using the test cohort.

RESULTS

The diagnostic accuracy and area under the curve of the deep-learning algorithm were 0.81 and 0.81, respectively, in the independent test data set. The rate of correct responses in the test data set was significantly higher for the algorithm than for the physician's consensus (81.0% vs . 66.2%; P = 0.034). Furthermore, the accuracy of the algorithm was greater than that of each individual physician.

CONCLUSIONS

We developed a deep-learning algorithm capable of suggesting the presence of cervical spinal cord compression on cervical radiography and highlighting the suspected levels on radiographic imaging when cord compression is identified. The diagnostic accuracy of the algorithm was greater than that of spine physicians.

LEVEL OF EVIDENCE

Level IV.

摘要

研究设计

横断面研究。

目的

验证一种深度学习算法对X线片上因退行性椎管狭窄导致的颈髓压迫的诊断准确性。

背景数据总结

退行性颈椎病的诊断常常延迟,导致治疗不当。疑似退行性颈椎病的筛查工具将有助于识别需要详细体格评估的患者。

材料与方法

来自240例患者(120例磁共振成像显示颈椎管狭窄,120例年龄和性别匹配的对照)的数据被随机分为训练数据集(n = 198)和测试数据集(n = 42)。使用名为EfficientNetB2的卷积神经网络模型以及训练数据集的X线片和磁共振成像数据构建旨在识别X线片上疑似狭窄节段的深度学习算法。计算独立测试数据集的接受者操作特征曲线的准确性和曲线下面积。最后,使用测试队列比较该算法与10名医生之间的正确诊断数量。

结果

在独立测试数据集中,深度学习算法的诊断准确性和曲线下面积分别为0.81和0.81。该算法在测试数据集中的正确反应率显著高于医生的共识(81.0%对66.2%;P = 0.034)。此外,该算法的准确性高于每位个体医生。

结论

我们开发了一种深度学习算法,能够在颈椎X线片上提示颈髓压迫的存在,并在识别脊髓压迫时在X线影像上突出显示疑似节段。该算法的诊断准确性高于脊柱科医生。

证据级别

IV级。

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