College of Medicine, California Northstate University, Elk Grove, CA, United States of America.
College of Medicine, California Northstate University, Elk Grove, CA, United States of America.
Toxicol Appl Pharmacol. 2022 Sep 1;450:116164. doi: 10.1016/j.taap.2022.116164. Epub 2022 Jul 14.
Substance use (SU) during pregnancy is on the rise, posing significant risks to the developing fetus. The adverse impact of maternal alcohol and nicotine use during the perinatal period on offspring health has been well established, including their associations with adverse cardiovascular health in offspring. However, limited studies examine the impact of other well-known SU utilized during pregnancy on offspring's cardiovascular health. This review summarizes the proposed mechanism of action of four commonly utilized substances: cocaine, marijuana, methamphetamine, and opioids, and their cardiovascular impact. Furthermore, we will review the current understanding of the adverse impact of substance use during pregnancy on offspring's cardiovascular system based on existing studies. This review will also highlight possible molecular mechanisms underlying the in-utero adverse programming of offspring's cardiovascular system secondary to SU in pregnancy and address the gaps in current understanding of how SU adversely impacts the developing cardiovascular system of offspring in utero.
怀孕期间物质使用（SU）呈上升趋势，对发育中的胎儿构成重大风险。母体在围产期内使用酒精和尼古丁会对后代健康产生不良影响，这一点已得到充分证实，包括它们与后代心血管健康不良的关联。然而，有限的研究调查了在怀孕期间使用其他已知的 SU 对后代心血管健康的影响。本综述总结了四种常用物质（可卡因、大麻、甲基苯丙胺和阿片类药物）的作用机制及其对心血管系统的影响。此外，我们将根据现有研究，回顾怀孕期间物质使用对后代心血管系统的不良影响的现有认识。本综述还将重点介绍由于 SU 在怀孕期间对后代心血管系统的宫内不良编程而导致的潜在分子机制，并解决当前对 SU 如何在子宫内对后代发育中的心血管系统产生不利影响的理解差距。
