妊娠期间接种 COVID-19 疫苗后母婴血液中的细胞因子水平与未接种疫苗对照相比。
Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls.
机构信息
Department of Pediatrics, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States of America.
Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, United States of America.
出版信息
J Reprod Immunol. 2023 Mar;156:103821. doi: 10.1016/j.jri.2023.103821. Epub 2023 Jan 29.
The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collected. Samples were analyzed utilizing a LEGENDplex 13-plex human anti-viral response cytokine panel. Maternal IP-10 and IFN-λ2/3 were lower in the vaccinated cohort. In the infants, levels were lower for IL-1β, IFN-λ2/3, and GM-CSF, and higher for IFN-λ1 in the vaccinated cohort. Vaccination against SARS-CoV-2 during pregnancy did not lead to elevations in cytokines in mothers or infants.
本研究的目的是比较接种 SARS-CoV-2 疫苗和未接种疫苗的孕妇在分娩时的母体和婴儿细胞因子谱。本前瞻性队列研究纳入了母婴对，采集了母亲血液以及婴儿和/或脐带血样本。利用 LEGENDplex 13 plex 人类抗病毒反应细胞因子面板进行了样本分析。接种疫苗组的母体 IP-10 和 IFN-λ2/3 较低。在婴儿中，接种疫苗组的 IL-1β、IFN-λ2/3 和 GM-CSF 水平较低，IFN-λ1 水平较高。妊娠期间接种 SARS-CoV-2 疫苗不会导致母亲或婴儿细胞因子升高。
Zotero 插件