Department of Pediatrics, Boston Medical Center, Boston, MA, United States.
Boston University School of Medicine, Boston, MA, United States.
J Perinatol. 2022 Oct;42(10):1319-1327. doi: 10.1038/s41372-022-01391-9. Epub 2022 Apr 21.
SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy.
Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay.
In comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p < 0.05) and IL-8 uniquely elevated in COVID infant samples (p < 0.05). Significant elevations in IL-6, IP-10, and IL-8 were found among both early (1st/2nd Trimester) and late (3rd Trimester) maternal SARS-CoV-2 infections.
Maternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health.
SARS-CoV-2 感染会导致成年人产生大量炎症细胞因子，但母体 SARS-CoV-2 感染妊娠的婴儿细胞因子特征尚未得到充分描述。本研究旨在评估 COVID-19 孕妇中母亲和婴儿的细胞因子谱。
对 31 例妊娠合并 SARS-CoV-2 感染（COVID）的母婴对的分娩时血清样本进行了检测，并与 29 例对照母婴对（Control）进行了比较。使用 13 plex 细胞因子测定法对样本进行了评估。
与对照组相比，COVID 母婴样本中白细胞介素 (IL)-6 和干扰素诱导蛋白 10 (IP-10) 升高（p < 0.05），COVID 婴儿样本中 IL-8 升高（p < 0.05）。在早期（1 至 2 妊娠期）和晚期（3 妊娠期）的 SARS-CoV-2 感染中，均发现 IL-6、IP-10 和 IL-8 显著升高。
妊娠期间的母体 SARS-CoV-2 感染与出生时母体和婴儿的炎症细胞因子增加有关，这可能会影响婴儿的长期健康。
