[Effect of isolation stress on ethanol pharmacokinetics in the blood of rats developing a taste for alcohol and in the stage of physical dependence on alcohol].

Head space chromatography was used to study the rate of ethanol excretion as a criterion of the activity of ethanol-oxidizing enzymatic system in rats. Isolation stress was shown to be one of the factors determining inclination to voluntary ethanol intake. The level of alcohol motivation directly correlated with the degree of stress. At the stage of physical dependence on ethanol the activity of ethanol-oxidizing enzymatic system and ethanol consumption were independent of the isolation stress, but related to profound biochemical and neurochemical variations.