[Pharmacokinetics of ethanol in the blood of rats in various stages of chronic alcoholism].

Kinetics of ethanol content, as a criterion of tolerance to the substance, was studied in rat blood at various steps of experimental alcoholism by means of gas-liquid chromatographic analysis. Initial addiction to alcohol was associated with its increased metabolism in the animals. Activation of ethanol-oxidizing enzymatic systems was observed in chronic alcoholization under conditions of free choice. This activation became statistically distinct after 10 days of the contact with alcohol. The activation of ethanol metabolism was maintained within 4 months and decreased after 8 months of alcoholization.