Wang Bo, Dai Zhuojun
Materials Synthetic Biology Center, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Angew Chem Int Ed Engl. 2023 Apr 17;62(17):e202217961. doi: 10.1002/anie.202217961. Epub 2023 Feb 24.
Microbial consortia consisting of phototrophs and heterotrophs have raised extensive attention due to their potential in sustainable biotechnology. The challenge remains in the selection of appropriate partners since most heterotrophic microorganisms cannot naturally use the intermediate carbohydrates secreted by autotrophic partners. In a recent study, the Ni Lab has developed a highly compatible autotrophic-heterotrophic symbiotic system comprising Synechococcus elongatus and Vibrio natriegens. V. natriegens (the sucrose utilization module) shows a high degree of nutritional complementarity and culturing compatibility with the engineered S. elongatus (the CO sequestration module). The combination of both species channels CO into various valuable chemicals, enabling carbon-negative biosynthesis.
由光合生物和异养生物组成的微生物群落因其在可持续生物技术方面的潜力而受到广泛关注。由于大多数异养微生物不能自然利用自养伙伴分泌的中间碳水化合物，因此选择合适的伙伴仍然是一个挑战。在最近的一项研究中，倪实验室开发了一种高度兼容的自养-异养共生系统，该系统由聚球藻和嗜盐栖热袍菌组成。嗜盐栖热袍菌（蔗糖利用模块）与工程化的聚球藻（CO固定模块）显示出高度的营养互补性和培养兼容性。这两种物种的组合将CO转化为各种有价值的化学品，实现碳负生物合成。
