Blood. 1987 Dec;70(6):1718-21.
The incidence of aplastic anemia was estimated in a 4-year study conducted in Israel and seven areas in Europe. Strict definition criteria were used, and all data and bone marrow specimens were reviewed by a panel of experienced hematologists. Complete ascertainment of cases was attempted by establishing a telephone network including all relevant hospitals in the study areas. The incidence of aplastic anemia was estimated to be less than three per million per year, a figure lower than previously reported. The most likely explanation for the differences among studies is variation in diagnostic criteria, which might lead to an overestimation of the incidence in some previous studies.
在以色列和欧洲七个地区进行的一项为期4年的研究中，对再生障碍性贫血的发病率进行了估算。研究采用了严格的定义标准，所有数据和骨髓标本均由一组经验丰富的血液学家进行审查。通过建立一个包括研究区域内所有相关医院的电话网络，试图实现病例的完全确诊。再生障碍性贫血的发病率估计低于每年百万分之三，这一数字低于先前报告的数字。不同研究结果存在差异的最可能原因是诊断标准的不同，这可能导致一些先前研究中发病率的高估。
