Swolin B, Rödjer S, Roupe G
Department of Clinical Chemistry, Sahlgren's Hospital, Gothenburg, Sweden.
Blood. 1987 Dec;70(6):1928-32.
Cytogenetic analysis of bone marrow cells and in vitro growth for bone marrow granulocytic-macrophage stem cells have been performed in 13 patients with mastocytosis, six with systemic mastocytosis, and seven with urticaria pigmentosa. Clones with chromosome abnormalities were found in five patients. The number of clusters and/or colonies after seven days in culture was increased in seven patients, compared with the growth in a control group. Three patients with chromosome abnormalities showed an abnormal growth pattern, yet exhibited normal peripheral blood values. Two patients with systemic mastocytosis had clones with chromosome abnormalities and some abnormal hematological values. The proportion of patients with chromosome abnormalities and an abnormal growth pattern was higher among these patients with mastocytosis than in healthy control subjects. These results may be of interest when discussing the origin of mast cell disorders and indicate an association with the myeloproliferative disorders.
对13例肥大细胞增多症患者（6例系统性肥大细胞增多症患者和7例色素性荨麻疹患者）进行了骨髓细胞的细胞遗传学分析以及骨髓粒系巨噬细胞干细胞的体外生长研究。在5例患者中发现了具有染色体异常的克隆。与对照组的生长情况相比，7例患者培养7天后的集簇和/或集落数量增加。3例具有染色体异常的患者表现出异常的生长模式，但外周血值正常。2例系统性肥大细胞增多症患者具有染色体异常的克隆和一些异常的血液学值。这些肥大细胞增多症患者中具有染色体异常和异常生长模式的患者比例高于健康对照受试者。在讨论肥大细胞疾病的起源时，这些结果可能会引起人们的兴趣，并表明与骨髓增殖性疾病有关。
