Rahmanuddin Syed, Jamil Asma, Chaudhry Ammar, Seto Tyler, Brase Jordyn, Motarjem Pejman, Khan Marjaan, Tomasetti Cristian, Farwa Umme, Boswell William, Ali Haris, Guidaben Danielle, Haseeb Rafay, Luo Guibo, Marcucci Guido, Rosen Steven T, Cai Wenli
Department of Diagnostic Radiology, City of Hope Comprehensive Cancer Center National Medical Center, Duarte, CA 91010, USA.
Department of Quality, Risk and Regulatory Management, City of Hope National Medical Center, Duarte, CA 91010, USA.
Cancers (Basel). 2023 Jan 20;15(3):651. doi: 10.3390/cancers15030651.
Cancer patients infected with COVID-19 were shown in a multitude of studies to have poor outcomes on the basis of older age and weak immune systems from cancer as well as chemotherapy. In this study, the CT examinations of 22 confirmed COVID-19 cancer patients were analyzed.
A retrospective analysis was conducted on 28 cancer patients, of which 22 patients were COVID positive. The CT scan changes before and after treatment and the extent of structural damage to the lungs after COVID-19 infection was analyzed. Structural damage to a lung was indicated by a change in density measured in Hounsfield units (HUs) and by lung volume reduction. A 3D radiometric analysis was also performed and lung and lesion histograms were compared.
A total of 22 cancer patients were diagnosed with COVID-19 infection. A repeat CT scan were performed in 15 patients after they recovered from infection. Most of the study patients were diagnosed with leukemia. A secondary clinical analysis was performed to show the associations of COVID treatment on the study subjects, lab data, and outcome on mortality. It was found that post COVID there was a decrease of >50% in lung volume and a higher density in the form of HUs due to scar tissue formation post infection.
It was concluded that COVID-19 infection may have further detrimental effects on the lungs of cancer patients, thereby, decreasing their lung volume and increasing their lung density due to scar formation.
众多研究表明，新冠病毒感染的癌症患者由于年龄较大、癌症及化疗导致免疫系统较弱，预后较差。在本研究中，对22例确诊为新冠病毒感染的癌症患者的CT检查结果进行了分析。
对28例癌症患者进行回顾性分析，其中22例患者新冠病毒检测呈阳性。分析了治疗前后的CT扫描变化以及新冠病毒感染后肺部结构损伤的程度。肺部结构损伤通过亨氏单位（HUs）测量的密度变化和肺容积减少来表示。还进行了三维放射测量分析，并比较了肺部和病变的直方图。
共有22例癌症患者被诊断为新冠病毒感染。15例患者感染康复后进行了重复CT扫描。大多数研究患者被诊断为白血病。进行了二次临床分析，以显示新冠治疗与研究对象、实验室数据及死亡率结局之间的关联。结果发现，感染新冠病毒后，由于感染后瘢痕组织形成，肺容积减少超过50%，且以亨氏单位形式表示的密度更高。
得出的结论是，新冠病毒感染可能会对癌症患者的肺部产生进一步的有害影响，从而因瘢痕形成导致肺容积减少和肺密度增加。
