生物性别会影响新冠疫情的结果。
Biological sex impacts COVID-19 outcomes.
机构信息
W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
出版信息
PLoS Pathog. 2020 Jun 22;16(6):e1008570. doi: 10.1371/journal.ppat.1008570. eCollection 2020 Jun.
The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.
当前的 2019 年新型冠状病毒病（COVID-19）大流行揭示了全球范围内男女在疾病结局方面的深刻差异。在美国，有关 COVID-19 病例、住院和死亡方面的男女差异的报告和分析一直不一致。我们旨在提高对 COVID-19 中男性偏倚严重结局的认识，重点介绍包括血管紧张素转换酶 2（ACE2）的表达和活性以及抗病毒免疫在内的机制差异。我们还强调了与年龄和种族相关的合并症的性别差异如何影响 COVID-19 中男性偏倚的结局。
Zotero 插件