Han Wei, Kong Rui, Wang Nan, Bao Wen, Mao Xinli, Lu Jie
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Zhejiang 317099, China.
Cancers (Basel). 2023 Jan 26;15(3):776. doi: 10.3390/cancers15030776.
Esophageal and gastric cancers are common diseases with high morbidity and mortality; thus, early detection and treatment are beneficial to improve prognosis. Confocal laser endomicroscopy (CLE) is a novel imaging technique that permits the histological analysis of tissues during endoscopy. CLE has been shown to uniquely affect the diagnosis of early upper gastrointestinal cancers. Relevant literature was searched using PubMed and Google Scholar databases. Despite inherent flaws, CLE can reduce tissue damage and improve diagnostic accuracy to a certain extent. CLE in combination with other imaging methods can help enhance the detection rate and avoid unnecessary biopsies in the management of esophageal or gastric cancer and precancerous lesions. CLE is of great significance in the diagnosis and surveillance of early cancers of the upper gastrointestinal tract. Further technical innovations and the standardisation of CLE will make it more responsive to the needs of routine clinical applications.
食管癌和胃癌是发病率和死亡率都很高的常见疾病；因此，早期发现和治疗有利于改善预后。共聚焦激光内镜显微术（CLE）是一种新型成像技术，可在内镜检查期间对组织进行组织学分析。已证明CLE对早期上消化道癌症的诊断具有独特影响。使用PubMed和谷歌学术数据库检索了相关文献。尽管存在固有缺陷，但CLE在一定程度上可以减少组织损伤并提高诊断准确性。CLE与其他成像方法相结合有助于提高食管癌或胃癌及癌前病变管理中的检出率并避免不必要的活检。CLE在上消化道早期癌症的诊断和监测中具有重要意义。进一步的技术创新和CLE的标准化将使其更能满足常规临床应用的需求。
