Russo Giorgio Ivan, Asmundo Maria Giovanna, Lo Giudice Arturo, Trefiletti Giuseppe, Cimino Sebastiano, Ferro Matteo, Lombardo Riccardo, De Nunzio Cosimo, Morgia Giuseppe, Piombino Eliana, Failla Maria, Caltabiano Rosario, Broggi Giuseppe
Urology Section, Department of Surgery, University of Catania, 95124 Catania, Italy.
Department of Urology, European Institute of Oncology, IRCCS, 20139 Milan, Italy.
Cancers (Basel). 2023 Feb 2;15(3):948. doi: 10.3390/cancers15030948.
Prostate Cancer (PCa) is still ranked as the first cancer in the male population and evidences have suggested an alteration of glycemic and lipidic metabolism that are related to its progression and prognosis. The aim of the study is to investigate associations between enzymes' expression, especially involved in the lipidic pathway, and PCa aggressiveness. We retrospectively analyzed data from 390 patients with PCa or benign prostatic hyperplasia (BPH) at the Department of Urology, University of Catania. Immunohistochemical slides were evaluated for the expression of proteins related to glucose and lipidic metabolism. A total of 286 were affected by PCa while 104 by BPH. We demonstrated that ATP-lyase (odds ratio [OR]: 1.71; < 0.01), fatty acid synthase (OR: 4.82; < 0.01), carnitine palmitoyl transferase-1a (OR: 2.27; < 0.05) were associated with androgen receptor (AR) expression. We found that steaoryl Co-A desaturase expression in PCa patients with total cholesterol ≥ 200 mg/dL was independently associated with ISUP ≥4 (OR: 4.22; = 0.049). We found that CPT-1a+ was associated with biochemical recurrence (hazard ratio: 1.94; = 0.03]). Our results support the evidence that the manipulation of lipidic metabolism could serve in the future to contrast PCa progression.
前列腺癌（PCa）在男性群体中仍位居癌症首位，有证据表明血糖和脂质代谢的改变与前列腺癌的进展及预后相关。本研究旨在调查尤其是参与脂质途径的酶表达与前列腺癌侵袭性之间的关联。我们回顾性分析了卡塔尼亚大学泌尿外科390例前列腺癌或良性前列腺增生（BPH）患者的数据。对免疫组织化学切片进行评估，以检测与葡萄糖和脂质代谢相关的蛋白质表达。其中共有286例为前列腺癌患者，104例为良性前列腺增生患者。我们证明，ATP裂解酶（优势比[OR]：1.71；P<0.01）、脂肪酸合酶（OR：4.82；P<0.01）、肉碱棕榈酰转移酶-1a（OR：2.27；P<0.05）与雄激素受体（AR）表达相关。我们发现，总胆固醇≥200mg/dL的前列腺癌患者中，硬脂酰辅酶A去饱和酶表达与国际泌尿病理学会（ISUP）分级≥4独立相关（OR：4.22；P=0.049）。我们发现，CPT-1a阳性与生化复发相关（风险比：1.94；P=0.03）。我们的结果支持以下证据，即对脂质代谢的调控未来可能有助于对抗前列腺癌的进展。
