Modenese Alberto
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy.
Healthcare (Basel). 2023 Jan 27;11(3):358. doi: 10.3390/healthcare11030358.
The aim of this ecological study is to evaluate correlations between the number of COVID-19 vaccine doses administered in three Italian provinces-one in the south, one in the center and one in the north of the country-and the registered numbers of COVID-19 cases in the same areas. The period of January 2021-September 2022 was considered, with specific analysis for fractions of times corresponding to the spread in Italy of the different SARS-CoV-2 variants. The results confirm the reduction of the effectiveness of the vaccines in preventing new COVID-19 cases in Italy, regardless of latitude, after the appearance of the first omicron variants. The new variants omicron 4 and 5 showed an extremely high spread during the Italian summer months; fortunately, the effects of the vaccinations in preventing new cases was improved compared to the previous omicron variants, showing a negative correlation between the new COVID-19 cases and the number of vaccine doses administered.
这项生态学研究的目的是评估意大利三个省份(该国南部一个、中部一个和北部一个)接种的新冠疫苗剂量数量与同一地区新冠病例登记数量之间的相关性。研究考虑了2021年1月至2022年9月这一时期,并对与不同SARS-CoV-2变体在意大利传播相对应的时间段进行了具体分析。结果证实,在首个奥密克戎变体出现后,无论纬度如何,意大利疫苗预防新冠新病例的有效性均有所降低。新的奥密克戎4和5变体在意大利夏季月份传播极广;幸运的是,与之前的奥密克戎变体相比,疫苗预防新病例的效果有所改善,新冠新病例数量与接种的疫苗剂量数量之间呈负相关。