Weidner C, Repérant J, Kirpitchnikova E, Miceli D, Desroches A, Rio J P
Laboratoire of Neurochimie-Anatomie, Université Paris VI, France.
Brain Res. 1987 Sep 1;419(1-2):357-63. doi: 10.1016/0006-8993(87)90608-1.
The retinal projection of an imperfect albino quail mutant with a sex-linked recessive gene was examined 2 weeks-16 months post-hatch using various histological methods. During the first weeks the visual system was normal. Initial signs of buphthalmos, a form of spontaneous glaucoma, appeared between the 3d and 5th months. Its development induced a degeneration of the retinal projections according to a relatively precise sequence progressing from the mesencephalic tegmentum to the optic tectum, then from the pretectum to the thalamus. The data suggest that the degeneration of the optic axons results from their mechanical compression due to the increased intraocular pressure.
