Riskind P N, Kolodny J M, Larsen P R
Department of Neurology, Massachusetts General Hospital, Boston 02114.
Brain Res. 1987 Sep 8;420(1):194-8. doi: 10.1016/0006-8993(87)90260-5.
The brain topographical distribution of type II 5'-monodeiodinase (5'D-II), which converts thyroxine (T4) to triiodothyronine (T3), was studied in euthyroid and hypothyroid rats. Low levels of 5'D-II activity were detected in the median eminence, but not in any other brain regions of euthyroid rats. The arcuate nucleus and median eminence were also the sites of highest 5'D-II activity in brains of hypothyroid rats. Under these conditions, the paraventricular nucleus contained almost no detectable 5'D-II, while intermediate enzyme activity was present in other medial basal hypothalamic sites.
在甲状腺功能正常和甲状腺功能减退的大鼠中，研究了将甲状腺素（T4）转化为三碘甲状腺原氨酸（T3）的II型5'-单脱碘酶（5'D-II）的脑地形图分布。在甲状腺功能正常的大鼠中，在正中隆起中检测到低水平的5'D-II活性，但在其他任何脑区均未检测到。弓状核和正中隆起也是甲状腺功能减退大鼠脑中5'D-II活性最高的部位。在这些条件下，室旁核几乎检测不到5'D-II，而在下丘脑内侧基底部的其他部位存在中等水平的酶活性。
