Department of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Int J Environ Res Public Health. 2023 Jan 27;20(3):2263. doi: 10.3390/ijerph20032263.
CD163, a cell membrane surface molecule specifically expressed by macrophages with an anti-inflammatory phenotype, participates in innate immunity. The purpose of the study was to evaluate the clinical utility of sCD163 in septic patients in comparison to other parameters associated with infections, mainly PCT, CRP and IL-18.
Serum samples were obtained from 40 septic patients on the ICU admission day, 3rd and 5th study days. The control group consisted of 30 healthy volunteers from whom the specimen was collected once. An enzyme-linked immunosorbent assay (ELISA) was used to determine the concentrations of sCD163 and IL-18. CRP and PCT records, among others, were provided by the hospital.
Septic shock was associated with the highest concentrations of sCD163 and IL-18. Admission values of sCD163 significantly contributed to mortality prediction in septic patients.
The concentration of sCD163 determined on the ICU admission day may potentially be utilized in estimation of the odds of death among septic patients.
CD163 是一种细胞表面分子，仅在具有抗炎表型的巨噬细胞中表达，参与固有免疫。本研究旨在评估 sCD163 在脓毒症患者中的临床应用价值，并与其他与感染相关的参数（主要是 PCT、CRP 和 IL-18）进行比较。
在 ICU 入院当天、第 3 天和第 5 天，采集 40 例脓毒症患者的血清样本。对照组由 30 名来自医院的健康志愿者组成，仅采集一次样本。采用酶联免疫吸附试验（ELISA）测定 sCD163 和 IL-18 的浓度。此外，还提供了 CRP 和 PCT 等记录。
脓毒性休克与 sCD163 和 IL-18 的最高浓度相关。入院时 sCD163 的浓度对脓毒症患者的死亡率预测有显著贡献。
在 ICU 入院当天测定的 sCD163 浓度可能有助于评估脓毒症患者的死亡概率。
