Pilowsky P M, Morris M J, Minson J B, West M J, Chalmers J P, Willoughby J O, Blessing W W
Department of Medicine, Flinders University of South Australia, Bedford Park.
Brain Res. 1987 Sep 15;420(2):380-4. doi: 10.1016/0006-8993(87)91261-3.
The role of bulbospinal neuropeptide Y (NPY)-containing neurons of the rostral ventrolateral medulla in the rabbit in mediating the increase in blood pressure that occurs during inhibition of cells in the caudal ventrolateral medulla was investigated in urethane-anaesthetized rabbits. In the present experiments bilateral injections of the GABA agonist, muscimol, into the caudal ventrolateral medulla elicited a slowly-developing rise in arterial pressure that was maximal 15 min after the injection. Accompanying this increase in arterial pressure was an increase in the release of NPY-like immunoreactivity (NPY-LI) into the spinal subarachnoid space. This pattern of response is similar to that seen after direct chemical stimulation of the NPY-containing cells of the rostral ventrolateral medulla. Taken together, these findings suggest that tonically active neurons in the caudal ventrolateral medulla exert their effects by inhibiting sympathoexcitatory NPY-containing neurons whose cell bodies are situated in the rostral ventrolateral medulla.
在氨基甲酸乙酯麻醉的家兔中，研究了延髓头端腹外侧含延髓脊髓神经肽Y（NPY）的神经元在介导延髓尾端腹外侧细胞抑制过程中发生的血压升高方面的作用。在本实验中，向延髓尾端腹外侧双侧注射GABA激动剂蝇蕈醇，引起动脉血压缓慢上升，注射后15分钟达到最大值。伴随动脉血压升高的是NPY样免疫反应性（NPY-LI）释放到脊髓蛛网膜下腔的增加。这种反应模式与直接化学刺激延髓头端腹外侧含NPY的细胞后所见的模式相似。综上所述，这些发现表明，延髓尾端腹外侧的紧张性活动神经元通过抑制其细胞体位于延髓头端腹外侧的含NPY的交感兴奋神经元来发挥作用。
