Stewart D J, Vanderwolf C H
Department of Psychology, University of Western Ontario, London, Canada.
Brain Res. 1987 Oct 13;423(1-2):101-8. doi: 10.1016/0006-8993(87)90829-8.
Ibotenic acid injections in the septal nuclei of the forebrain produced severe cell loss in the dorsal lateral septal nucleus and the septohippocampal nucleus. Chronic recording of hippocampal and neocortical slow-wave activity and muscle activity showed that the ibotenic acid treatment had selectively abolished the atropine-sensitive (presumably cholinergic) form of hippocampal rhythmical slow activity (RSA) normally seen during the tonic component of active sleep. Large-amplitude irregular activity (LIA), that is normally associated with waking immobility and quiet sleep, and the atropine-resistant (probably serotonergic) RSA that normally accompanies phasic muscular activity during active sleep, were also somewhat depressed. However, clear RSA was seen during phasic muscular activity in active sleep and LIA was clearly seen during quiet sleep in all rats. Neocortical activity was not affected by the ibotenic acid treatment. The results are consistent with the hypothesis that, both in the sleeping and the waking state, RSA can be produced by either of two distinctive inputs to the hippocampus. No support was found for the hypothesis that RSA during active sleep has a different basis than RSA in the waking state.
在前脑隔核注射鹅膏蕈氨酸导致背外侧隔核和隔海马核严重细胞丢失。对海马和新皮质慢波活动以及肌肉活动的长期记录表明，鹅膏蕈氨酸处理选择性地消除了在主动睡眠的紧张性成分期间通常可见的对阿托品敏感（推测为胆碱能）形式的海马节律性慢活动（RSA）。通常与清醒不动和安静睡眠相关的大幅度不规则活动（LIA），以及在主动睡眠期间与相位性肌肉活动通常相伴的对阿托品抵抗（可能是5-羟色胺能）的RSA，也有所降低。然而，在所有大鼠的主动睡眠相位性肌肉活动期间均可见清晰的RSA，在安静睡眠期间均可见清晰的LIA。新皮质活动不受鹅膏蕈氨酸处理的影响。这些结果与以下假设一致：在睡眠和清醒状态下，RSA可由海马的两种不同输入之一产生。未发现支持以下假设的证据：主动睡眠期间的RSA与清醒状态下的RSA有不同的基础。
