Ćwiklińska-Haszcz Agnieszka, Żarnowski Tomasz, Wróbel-Dudzińska Dominika, Kosior-Jarecka Ewa
Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, 20-059 Lublin, Poland.
Int J Environ Res Public Health. 2023 Feb 3;20(3):2759. doi: 10.3390/ijerph20032759.
The aim of the study was to retrospectively evaluate the efficacy and safety of GATT during a 6-month observation period.
The studied group consisted of 69 open-angle glaucoma patients treated with GATT as the only procedure or in combination with cataract surgery. Patients were assessed 1 day, 10 days, 1 month, 3 months, and 6 months after the surgery via standard ophthalmic examination including VF, IOP, and BCVA. The number of medications taken daily and possible complications were checked. Two criteria of success were established (S1: IOP decrease by 30% and S2: IOP lower than 18 mm Hg).
Before the surgery, the mean IOP was 26.94 mmHg and significantly decreased after GATT to 15.59 mmHg at 6M. BCVA did not significantly differ between the visits. The mean MD did not change significantly within the 6-month observation period (-8.20 dB vs. -8.16 dB, = 0.9824), similar to the mean VFI (64.31% vs. 63.05%, = 0.8571). A 30% IOP decrease at 6M visit was obtained in 95.6% of patients, and 37.7% needed medications to stabilize IOP. An IOP lower than 18 mmHg at 6M was obtained in 91.3% of studied patients after the GATT procedure, and in 58.0% without additional medications. The mean number of medications received daily decreased significantly at 6M compared to preoperative results (2.59 at inclusion vs. 0.76 at 6M, = 0.0004). The most frequent complication after surgery was hyphema, which resolved spontaneously within 10 days.
The 6-month observation showed that GATT is a minimally invasive glaucoma-surgery technique that enables an effective and safe IOP decrease.
本研究旨在回顾性评估在6个月观察期内GATT的疗效和安全性。
研究组由69例开角型青光眼患者组成，这些患者接受GATT作为唯一手术或与白内障手术联合进行。术后1天、10天、1个月、3个月和6个月通过包括视野（VF）、眼压（IOP）和最佳矫正视力（BCVA）在内的标准眼科检查对患者进行评估。检查每日服用药物的数量和可能出现的并发症。确立了两个成功标准（S1：眼压降低30%和S2：眼压低于18 mmHg）。
手术前，平均眼压为26.94 mmHg，GATT术后6个月时显著降至15.59 mmHg。各次就诊时BCVA无显著差异。在6个月观察期内，平均平均缺损（MD）无显著变化（-8.20 dB对-8.16 dB，P = 0.9824），平均视野指数（VFI）情况类似（64.31%对63.05%，P = 0.8571）。95.6%的患者在术后6个月时眼压降低30%，37.7%的患者需要药物来稳定眼压。GATT手术后，91.3%的研究患者在6个月时眼压低于18 mmHg，58.0%的患者无需额外用药。与术前结果相比，6个月时每日接受药物的平均数量显著减少（纳入时为2.59种对6个月时为0.76种，P = 0.0004）。手术后最常见的并发症是前房积血，在10天内自发消退。
6个月的观察表明，GATT是一种微创青光眼手术技术，能够有效且安全地降低眼压。
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