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由于癌症对蛋氨酸的依赖，[C]蛋氨酸优于 [F]脱氧葡萄糖用于多种癌症类型的 PET 成像。

Superiority of [C]methionine over [F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer.

机构信息

AntiCancer Inc., 7917 Ostrow Str., San Diego, CA 92111-3604, USA.

Department of Surgery, University of California, San Diego, CA 92037-7220, USA.

出版信息

Int J Mol Sci. 2023 Jan 18;24(3):1935. doi: 10.3390/ijms24031935.

DOI:10.3390/ijms24031935
PMID:36768257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9915427/
Abstract

Positron emission tomography (PET) is widely used to detect cancers. The usual isotope for PET imaging of cancer is [F]deoxyglucose. The premise of using [F]deoxyglucose is that cancers are addicted to glucose (The Warburg effect). However, cancers are more severely addicted to methionine (The Hoffman effect). [C]methionine PET (MET-PET) has been effectively used for the detection of glioblastoma and other cancers in the brain, and in comparison, MET-PET has been shown to be more sensitive and accurate than [F]deoxyglucose PET (FDG-PET). However, MET-PET has been limited to cancers in the brain. The present report describes the first applications of MET-PET to cancers of multiple organs, including rectal, bladder, lung, and kidney. The results in each case show that MET-PET is superior to FDG-PET due to the methionine addiction of cancer and suggest that the broad application of MET-PET should be undertaken for cancer detection.

摘要

正电子发射断层扫描（PET）广泛用于癌症检测。癌症 PET 成像常用的同位素是[F]脱氧葡萄糖。使用[F]脱氧葡萄糖的前提是癌症对葡萄糖（沃伯格效应）有依赖性。然而，癌症对蛋氨酸（霍夫曼效应）的依赖性更严重。[C]蛋氨酸 PET（MET-PET）已有效地用于脑胶质瘤和其他脑部癌症的检测，相比之下，MET-PET 被证明比[F]脱氧葡萄糖 PET（FDG-PET）更敏感和准确。然而，MET-PET 仅限于脑部癌症。本报告描述了 MET-PET 首次应用于包括直肠、膀胱、肺和肾在内的多种器官癌症的情况。在每种情况下的结果均表明，由于癌症对蛋氨酸的依赖性，MET-PET 优于 FDG-PET，并提示应广泛开展 MET-PET 用于癌症检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e16/9915427/f146b142d17f/ijms-24-01935-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e16/9915427/f146b142d17f/ijms-24-01935-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e16/9915427/54dc00623b6f/ijms-24-01935-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e16/9915427/bb93cfaf60d0/ijms-24-01935-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e16/9915427/f146b142d17f/ijms-24-01935-g005.jpg

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