Center for Biomechanics and Bioengineering, Beijing Key Laboratory of Engineered Construction and Mechanobiology and Key Laboratory of Microgravity (National Microgravity Laboratory), Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China.
School of Engineering Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2023 Jan 22;24(3):2197. doi: 10.3390/ijms24032197.
Microgravity exposure during spaceflight causes the disordered regulation of liver function, presenting a specialized mechano-biological coupling process. While YAP/TAZ serves as a typical mechanosensitive pathway involved in hepatocyte metabolism, it remains unclear whether and how it is correlated with microgravity-induced liver dysfunction. Here, we discussed liver function alterations induced by spaceflight or simulated effects of microgravity on Earth. The roles of YAP/TAZ serving as a potential bridge in connecting liver metabolism with microgravity were specifically summarized. Existing evidence indicated that YAP/TAZ target gene expressions were affected by mechanotransductive pathways and phase separation, reasonably speculating that microgravity might regulate YAP/TAZ activation by disrupting these pathways via cytoskeletal remodeling or nuclear deformation, or disturbing condensates formation via diffusion limit, and then breaking liver homeostasis.
在太空飞行中，微重力会导致肝功能紊乱，呈现出一种特殊的力学生物耦合过程。YAP/TAZ 作为一种参与肝细胞代谢的典型机械敏感途径，其是否以及如何与微重力诱导的肝功能障碍相关仍不清楚。在这里，我们讨论了由太空飞行或模拟微重力引起的肝功能改变。特别总结了 YAP/TAZ 作为连接肝脏代谢与微重力的潜在桥梁的作用。现有证据表明，YAP/TAZ 的靶基因表达受机械转导途径和相分离的影响，可以合理推测，微重力可能通过细胞骨架重塑或核变形破坏这些途径来调节 YAP/TAZ 的激活，或者通过扩散限制干扰凝聚体的形成，从而破坏肝脏的内稳态。
