Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.
Int J Mol Sci. 2023 Jan 22;24(3):2218. doi: 10.3390/ijms24032218.
As an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19, mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the successful implementation of the systemic delivery of mRNA for safe human consumption. In this manuscript, we provide an overview of current mRNA therapeutic applications and discuss key biological barriers to delivery and recent advances in the development of nonviral systems. The relevant challenges that LNPs face in achieving cost-effective and widespread clinical implementation when delivering mRNA are likewise discussed.
作为治疗和预防从癌症到 COVID-19 等各种疾病的一种有吸引力的替代方法，mRNA 已经显示出显著的临床效果。纳米技术促进了 mRNA 的系统递送在安全的人类消费中的成功实施。在本文中，我们提供了当前 mRNA 治疗应用的概述，并讨论了传递过程中的关键生物障碍和非病毒系统的最新进展。同样，本文还讨论了当 LNP 传递 mRNA 时，在实现具有成本效益和广泛临床应用方面所面临的相关挑战。
