Faculty of Agricultural Sciences and Landscape Architecture, Osnabrueck University of Applied Sciences, Am Kruempel 31, 49090 Osnabrueck, Germany.
Int J Mol Sci. 2023 Jan 26;24(3):2409. doi: 10.3390/ijms24032409.
Liver cancers are rising worldwide. Between molecular and epidemiological studies, a research gap has emerged which might be amenable to the technique of metabolomics. This review investigates the current understanding of liver cancer's trends, etiology and its correlates with existing literature for hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and hepatoblastoma (HB). Among additional factors, the literature reports dysfunction in the tricarboxylic acid metabolism, primarily for HB and HCC, and point mutations and signaling for CCA. All cases require further investigation of upstream and downstream events. All liver cancers reported dysfunction in the WNT/β-catenin and P13K/AKT/mTOR pathways as well as changes in FGFR. Metabolites of IHD1, IDH2, miRNA, purine, Q10, lipids, phosphatidylcholine, phosphatidylethanolamine, acylcarnitine, 2-HG and propionyl-CoA emerged as crucial and there was an attempt to elucidate the WNT/β-catenin and P13K/AKT/mTOR pathways metabolomically.
肝癌在全球范围内呈上升趋势。在分子和流行病学研究之间，出现了一个研究空白，可能适合代谢组学技术。本综述调查了肝癌趋势、病因及其与肝细胞癌 (HCC)、胆管细胞癌 (CCA) 和肝母细胞瘤 (HB) 现有文献的相关性的当前理解。在其他因素中，文献报告三羧酸代谢功能障碍，主要是针对 HB 和 HCC，以及 CCA 的点突变和信号传导。所有病例都需要进一步调查上游和下游事件。所有报告的肝癌在 WNT/β-catenin 和 P13K/AKT/mTOR 途径以及 FGFR 变化方面均存在功能障碍。IHD1、IDH2、miRNA、嘌呤、Q10、脂质、磷脂酰胆碱、磷脂酰乙醇胺、酰基辅酶 A、2-HG 和丙酰辅酶 A 的代谢物成为关键，并且试图从代谢组学角度阐明 WNT/β-catenin 和 P13K/AKT/mTOR 途径。
