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围生期因素对人类母乳干细胞中 IAPs 家族基因表达和多能性主要调控因子的影响：一项初步报告。

Influence of Perinatal Factors on Gene Expression of IAPs Family and Main Factors of Pluripotency: and in Human Breast Milk Stem Cells-A Preliminary Report.

机构信息

Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.

Student Scientific Society of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.

出版信息

Int J Mol Sci. 2023 Jan 27;24(3):2476. doi: 10.3390/ijms24032476.

DOI:10.3390/ijms24032476
PMID:36768802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9917041/
Abstract

Due to their therapeutic potential, mesenchymal stem cells are the subject of intensive research on the use of their potential in the treatment of, among others, neurodegenerative diseases or immunological diseases. They are among the newest in the field of medicine. The presented study aimed to evaluate the expression of eight genes from the IAP family and the gene regulating IAP--in stem cells derived from human milk, using the qPCR method. The relationships between the expression of genes under study and clinical data, such as maternal age, maternal BMI, week of pregnancy in which the delivery took place, bodyweight of the newborn, the number of pregnancies and deliveries, and the time elapsed since delivery, were also analyzed. The research was carried out on samples of human milk collected from 42 patients hospitalized in The Clinic of Obstetrics and Perinatology of the Independent Public Clinical Hospital No. 4, in Lublin. The conducted research confirmed the expression of the following genes in the tested material: and . Moreover, several dependencies of the expression of individual genes on the maternal BMI ( and ), the time since childbirth ( and ), the number of pregnancies and deliveries ( and ), the manner of delivery ( and ), preterm labor ( and ) were demonstrated. Additionally, we found positive relationships between gene expression of BIRC7, BIRC8 and XAF1 and the main factors of pluripotency: and . This work is the first to investigate the expression of genes from the IAPs family in mother's milk stem cells.

摘要

由于其治疗潜力，间充质干细胞是研究其在治疗神经退行性疾病或自身免疫性疾病等方面的潜在应用的热门对象。它们是医学领域的最新研究成果之一。本研究旨在使用 qPCR 方法评估来自 IAP 家族的 8 个基因和调节 IAP 的基因在人乳来源的干细胞中的表达。还分析了研究基因的表达与临床数据（如母亲年龄、母亲 BMI、分娩时的孕周、新生儿体重、妊娠和分娩次数以及分娩后时间）之间的关系。该研究在 42 名住院于卢布林独立公立临床医院第 4 妇产科诊所的患者的人乳样本上进行。所进行的研究证实了以下基因在测试材料中的表达： 和 。此外，还证明了个别基因的表达与母亲 BMI（ 和 ）、分娩后时间（ 和 ）、妊娠和分娩次数（ 和 ）、分娩方式（ 和 ）之间存在依赖性早产（ 和 ）。此外，我们发现 BIRC7、BIRC8 和 XAF1 基因表达与多能性的主要因素之间存在正相关： 和 。这项工作是首次研究 IAPs 家族基因在母乳干细胞中的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/6517e2743497/ijms-24-02476-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/2923b196d85e/ijms-24-02476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/6e1e911a747f/ijms-24-02476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/08505ac0e8cc/ijms-24-02476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/cfafe63674d9/ijms-24-02476-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/6517e2743497/ijms-24-02476-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/f3704d7f6a9a/ijms-24-02476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/c26fc3cc7384/ijms-24-02476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/dd3a1f61d78f/ijms-24-02476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/6faa53290fed/ijms-24-02476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/56028224654d/ijms-24-02476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/2923b196d85e/ijms-24-02476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/6e1e911a747f/ijms-24-02476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/08505ac0e8cc/ijms-24-02476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/cfafe63674d9/ijms-24-02476-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc0/9917041/6517e2743497/ijms-24-02476-g010.jpg

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