分娩方式、缩宫素使用和产妇年龄对脐带华通氏胶来源的干细胞基因表达的影响。
Influence of the Type of Delivery, Use of Oxytocin, and Maternal Age on Gene Expression in Stem Cells Derived from Wharton's Jelly within the Umbilical Cord.
机构信息
Department of Clinical Genetics, Medical University of Lublin, Poland.
Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland.
出版信息
Oxid Med Cell Longev. 2019 Dec 14;2019:1027106. doi: 10.1155/2019/1027106. eCollection 2019.
Abstract
The paper presents an evaluation of the gene expression in mesenchymal stem cells derived from Wharton's jelly within the umbilical cord, collected from 36 patients during labor. The study is the first one to show that the expression of in mesenchymal stem cells has been dependent on maternal age, birth order, route of delivery, and use of oxytocin. Our research proves that the gene expression in mesenchymal stem cells decreases with each subsequent pregnancy and delivery. Wharton's jelly stem cells obtained from younger women and during their first delivery, as well as patients treated with oxytocin, show higher gene expression when compared with the subsequent deliveries. This leads to a conclusion that they are characterized by a lower level of differentiation, which in turn results in their greater plasticity and greater proliferative potential. Probably, they are also clinically more useful.
摘要
本文评估了从脐带华通氏胶中分离的间充质干细胞的基因表达，这些细胞来自 36 名分娩产妇。这是首次研究表明，间充质干细胞中的表达取决于母体年龄、分娩顺序、分娩方式和催产素的使用。我们的研究证明，随着每次后续妊娠和分娩，间充质干细胞中的基因表达逐渐下降。与后续分娩相比，从年轻女性和第一次分娩中获得的华通氏胶干细胞以及接受催产素治疗的患者的基因表达更高。这表明它们分化程度较低，这反过来又导致它们具有更大的可塑性和更强的增殖潜力。可能，它们在临床上也更有用。
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本文引用的文献
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2
Oxytocin facilitates the proliferation, migration and osteogenic differentiation of human periodontal stem cells in vitro.
Arch Oral Biol. 2019 Mar;99:126-133. doi: 10.1016/j.archoralbio.2019.01.007. Epub 2019 Jan 19.
3
Priming with oxytocin and relaxin improves cardiac differentiation of adipose tissue-derived stem cells.
J Cell Biochem. 2019 Apr;120(4):5825-5834. doi: 10.1002/jcb.27868. Epub 2018 Oct 25.
4
Oxytocin effects on osteoblastic differentiation of Bone Marrow Mesenchymal Stem Cells from adult and aging female Wistar rats.
Exp Gerontol. 2018 Nov;113:58-63. doi: 10.1016/j.exger.2018.09.023. Epub 2018 Sep 27.
5
[Influence of obstetric factors on characteristics of umbilical cord blood transplants].
Gynecol Obstet Fertil Senol. 2018 Sep;46(9):639-644. doi: 10.1016/j.gofs.2018.07.005. Epub 2018 Aug 16.
6
The Oxytocin Receptor: From Intracellular Signaling to Behavior.
Physiol Rev. 2018 Jul 1;98(3):1805-1908. doi: 10.1152/physrev.00031.2017.
7
Oxytocin alters cell fate selection of rat neural progenitor cells in vitro.
PLoS One. 2018 Jan 18;13(1):e0191160. doi: 10.1371/journal.pone.0191160. eCollection 2018.
8
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9
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