长非编码 RNA 在昆虫中的最新进展与未来潜力。
Recent Advances and Future Potential of Long Non-Coding RNAs in Insects.
机构信息
Key Laboratory of Bio-Pesticide Innovation and Application of Guangdong Province, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China.
出版信息
Int J Mol Sci. 2023 Jan 30;24(3):2605. doi: 10.3390/ijms24032605.
Over the last decade, long non-coding RNAs (lncRNAs) have witnessed a steep rise in interest amongst the scientific community. Because of their functional significance in several biological processes, i.e., alternative splicing, epigenetics, cell cycle, dosage compensation, and gene expression regulation, lncRNAs have transformed our understanding of RNA's regulatory potential. However, most knowledge concerning lncRNAs comes from mammals, and our understanding of the potential role of lncRNAs amongst insects remains unclear. Technological advances such as RNA-seq have enabled entomologists to profile several hundred lncRNAs in insect species, although few are functionally studied. This article will review experimentally validated lncRNAs from different insects and the lncRNAs identified via bioinformatic tools. Lastly, we will discuss the existing research challenges and the future of lncRNAs in insects.
在过去的十年中，长非编码 RNA（lncRNA）在科学界引起了极大的兴趣。由于它们在多种生物学过程中的功能意义，如可变剪接、表观遗传学、细胞周期、剂量补偿和基因表达调控，lncRNA 改变了我们对 RNA 调控潜力的理解。然而，关于 lncRNA 的大部分知识都来自哺乳动物，我们对昆虫中 lncRNA 潜在作用的理解还不清楚。RNA-seq 等技术的进步使昆虫学家能够在昆虫物种中鉴定出数百种 lncRNA，尽管其中很少有进行功能研究。本文将综述不同昆虫中经过实验验证的 lncRNA 和通过生物信息学工具鉴定的 lncRNA。最后，我们将讨论现有的研究挑战和昆虫中 lncRNA 的未来。
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