Unidad de Investigación, Hospital General Universitario Dr. Balmis, ISABIAL, 03010 Alicante, Spain.
Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain.
Int J Mol Sci. 2023 Feb 3;24(3):2992. doi: 10.3390/ijms24032992.
The retina is among the highest organized tissues of the central nervous system. To achieve such organization, a finely tuned regulation of developmental processes is required to form the retinal layers that contain the specialized neurons and supporting glial cells to allow precise phototransduction. MicroRNAs are a class of small RNAs with undoubtful roles in fundamental biological processes, including neurodevelopment of the brain and the retina. This review provides a short overview of the most important findings regarding microRNAs in the regulation of retinal development, from the developmental-dependent rearrangement of the microRNA expression program to the key roles of particular microRNAs in the differentiation and maintenance of retinal cell subtypes.
视网膜是中枢神经系统中组织化程度最高的组织之一。为了实现这种组织，需要精细调节发育过程，形成包含专门神经元和支持胶质细胞的视网膜层，以允许精确的光转导。microRNAs 是一类小 RNA，在包括大脑和视网膜的神经发育等基本生物学过程中具有不可置疑的作用。本综述简要概述了 microRNAs 在视网膜发育调控中的重要发现，从发育依赖性 microRNA 表达程序重排到特定 microRNAs 在视网膜细胞亚型分化和维持中的关键作用。
