Gómez-Mayordomo Víctor, Alonso-Frech Fernando, Hernández-Barrera Valentín, Carabantes-Alarcon David, Zamorano-León José J, Lopez-de-Andrés Ana, Jiménez-García Rodrigo
Department of Neurology, Hospital Clínico San Carlos, San Carlos Research Health Institute (IdISSC), 28040 Madrid, Spain.
Department of Neurology, Institute of Neurosciences, Hospital Universitario Vithas La Milagrosa, Vithas Hospital Group, 28010 Madrid, Spain.
J Clin Med. 2023 Jan 23;12(3):902. doi: 10.3390/jcm12030902.
The incidence of hospitalizations of Parkinson´s disease (PD) in Spain suffered a steady rise from 1997 to 2012. However, data on the trends during the following decade (2010-2019) are lacking. Hospital admissions with a primary and secondary diagnosis of PD were selected using the Spanish National Hospital Discharge Database (SNHDD) for the period 2010-2019. The primary endpoint was the incidence of hospitalizations and in-hospital mortality, stratified in biannual periods. The incidence of PD hospitalizations increased progressively over time from 81.25 cases in 2010-2011 to 94.82 cases in 2018-2019 per 100,000 inhabitants. Male sex, age and comorbidity also increased progressively in PD inpatients. PD as a comorbid condition presented a higher increment (annual percentage of change, APC +1.71%, < 0.05) than PD as the main reason of hospitalization (APC +1.26%, < 0.05). In the multivariate regression model, factors associated with mortality were male sex (OR = 1.15, 95% CI 1.01-1.35), age (>80 years, OR = 12.76, 95% CI 3.96-29.64) and comorbidity (Charlson index ≥ 2, OR 1.77, 95% CI 1.69-1.85). Adjusted mortality by age, sex, comorbidity and diagnostic position remained stable. In conclusion, PD hospitalizations in Spain have increased, with a parallel increment in mean age, male sex and higher comorbidities. However, adjusted mortality remains unchanged. The burden of this disease may increase the complexity and costs of hospital care in the future.
1997年至2012年期间，西班牙帕金森病（PD）的住院发病率呈稳步上升趋势。然而，关于接下来十年（2010 - 2019年）的趋势数据却有所缺失。利用西班牙国家医院出院数据库（SNHDD）选取了2010年至2019年期间以PD作为主要和次要诊断的医院入院病例。主要终点是住院发病率和院内死亡率，按半年期进行分层。PD住院发病率随时间逐渐增加，从2010 - 2011年的每10万居民81.25例增至2018 - 2019年的94.82例。PD住院患者的男性、年龄和合并症也呈逐渐增加趋势。作为合并症的PD呈现出比作为住院主要原因的PD更高的增长率（年变化百分比，APC +1.71%，P < 0.05）（APC +1.26%，P < 0.05）。在多变量回归模型中，与死亡率相关的因素为男性（OR = 1.15，95%CI 1.01 - 1.35）、年龄（>80岁，OR = 12.76，95%CI 3.96 - 29.64）和合并症（Charlson指数≥2，OR 1.77，95%CI 1.69 - 1.85）。经年龄、性别、合并症和诊断位置调整后的死亡率保持稳定。综上所述，西班牙的PD住院率有所上升，同时平均年龄、男性比例和合并症也相应增加。然而，调整后的死亡率保持不变。这种疾病的负担可能会在未来增加医院护理的复杂性和成本。
