Lee Song-I, Chung Chaeuk, Park Dongil, Kang Da Hyun, Ju Ye-Rin, Lee Jeong Eun
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
J Clin Med. 2023 Jan 31;12(3):1118. doi: 10.3390/jcm12031118.
The influence of sex on the clinical characteristics and prognosis of coronavirus disease (COVID-19) patients is variable. This study aimed to evaluate COVID-19 management based on sex differences.
We retrospectively reviewed COVID-19 patients who were admitted to the tertiary hospital between January 2020 and March 2021. Logistic regression analysis was used to evaluate the factors associated with in-hospital mortality.
During the study period, 584 patients were admitted to our hospital. Among them, 305 patients (52.2%) were female, and 279 patients (47.8%) were male. Males were younger than females, and frailty scale was lower in males than in females. Fever was more common in males, and there was no difference in other initial symptoms. Among the underlying comorbidities, chronic obstructive disease was more common in males, and there were no significant differences in other comorbidities. Moreover, treatment, severity, and outcome did not significantly differ between the groups. The risk factors for in-hospital mortality were age, high white blood cell count, and c-reactive protein level.
We found no definite sex differences in the clinical characteristics and outcomes of COVID-19 patients. However, a better understanding of sex-dependent differences in COVID-19 patients could help in understanding and treating patients.
性别对冠状病毒病（COVID-19）患者的临床特征和预后的影响存在差异。本研究旨在基于性别差异评估COVID-19的治疗情况。
我们回顾性分析了2020年1月至2021年3月期间入住三级医院的COVID-19患者。采用逻辑回归分析评估与院内死亡相关的因素。
在研究期间，我院共收治584例患者。其中，女性305例（52.2%），男性279例（47.8%）。男性比女性年轻，男性的衰弱评分低于女性。发热在男性中更常见，其他初始症状无差异。在基础合并症中，慢性阻塞性肺疾病在男性中更常见，其他合并症无显著差异。此外，两组在治疗、严重程度和结局方面无显著差异。院内死亡的危险因素为年龄、高白细胞计数和C反应蛋白水平。
我们发现COVID-19患者的临床特征和结局不存在明确的性别差异。然而，更好地了解COVID-19患者的性别依赖性差异有助于理解和治疗患者。
