Lin Ting-Yi, Lai Yi-Fen, Chien Wu-Chien, Chen Yi-Hao, Chung Chi-Hsiang, Chen Jiann-Torng, Chen Ching-Long
Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
School of Public Health, National Defense Medical Center, Taipei City 11490, Taiwan.
J Clin Med. 2023 Feb 3;12(3):1211. doi: 10.3390/jcm12031211.
Many studies have demonstrated an increased cardiovascular (CV) risk in ankylosing spondylitis (AS) patients. Nevertheless, the influence of an endophthalmitis episode toward the future risks of acute myocardial infarction (AMI) in AS patients has been unclear. The objective of this study was to explore the impact of endophthalmitis on AMI risk in this particular patient population by a population-based retrospective cohort study with a follow-up period up to 16 years. Univariate and multivariate Cox regression analyses were used for the risk evaluation and the results were presented as crude and adjusted hazard ratios (HRs). Overall, we enrolled 557 AS patients with endophthalmitis as the study cohort and selected another 2228 matched AS patients without endophthalmitis as the comparison cohort. Comparing the comparison cohort, the study cohort showed a significantly higher overall AMI incidence rate with an adjusted HR of 1.631 ( < 0.001). In conclusion, endophthalmitis increased the risk of AMI in AS patients after adjusting for possible clinical confounders. Special attention and work-up are required for physicians when encountering a history of endophthalmitis in these special patient populations, especially when they are comorbid with other potential CV risk factors.
许多研究表明，强直性脊柱炎（AS）患者的心血管（CV）风险增加。然而，眼内炎发作对AS患者未来急性心肌梗死（AMI）风险的影响尚不清楚。本研究的目的是通过一项基于人群的回顾性队列研究，随访期长达16年，探讨眼内炎对这一特定患者群体中AMI风险的影响。采用单因素和多因素Cox回归分析进行风险评估，结果以粗风险比和调整后风险比（HR）表示。总体而言，我们纳入了557例患有眼内炎的AS患者作为研究队列，并选择另外2228例匹配的无眼内炎的AS患者作为对照队列。与对照队列相比，研究队列的总体AMI发病率显著更高，调整后的HR为1.631（<0.001）。总之，在调整可能的临床混杂因素后，眼内炎增加了AS患者发生AMI的风险。对于这些特殊患者群体中存在眼内炎病史的患者，尤其是当他们合并其他潜在CV风险因素时，医生需要给予特别关注并进行详细检查。
