Bartow S A, Pathak D R, Black W C, Key C R, Teaf S R
Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131.
Cancer. 1987 Dec 1;60(11):2751-60. doi: 10.1002/1097-0142(19871201)60:11<2751::aid-cncr2820601127>3.0.co;2-m.
A forensic autopsy series of 519 women more than 14 years old was studied for prevalence of benign, atypical, and occult malignant breast lesions. The women included Anglos (non-Hispanic whites), Hispanics, and American Indians from New Mexico and Eastern Arizona. These three ethnic/racial groups are at markedly different risk for the development of breast cancer (Anglo 89 of 100,000 women per year, Hispanic 45.5, and American Indian 24.9. There were striking ethnic/racial and age-related differences in both the prevalence and magnitude of all forms of nonproliferative and proliferative fibrocystic disease. The various subsets of fibrocystic disease were highly associated with each other. Such lesions as apocrine metaplasia, sclerosing adenosis, and lobular microcalcification showed as much difference according to ethnic/racial background and age as the more common cystic change and duct epithelial hyperplasia. Atypical lobular and ductal hyperplasia, carcinoma in situ, and occult invasive carcinoma were uncommon and also occurred in ethnic/racial groups in a pattern that parallels the cancer risk in those groups.
对519名14岁以上女性进行法医尸检，研究良性、非典型和隐匿性恶性乳腺病变的患病率。这些女性包括来自新墨西哥州和亚利桑那州东部的盎格鲁人（非西班牙裔白人）、西班牙裔和美国印第安人。这三个种族/民族群体患乳腺癌的风险明显不同（盎格鲁人每年每10万名女性中有89例，西班牙裔为45.5例，美国印第安人为24.9例）。在所有形式的非增殖性和增殖性纤维囊性疾病的患病率和程度方面，存在显著的种族/民族和年龄相关差异。纤维囊性疾病的各个亚组之间高度相关。诸如大汗腺化生、硬化性腺病和小叶微钙化等病变，根据种族/民族背景和年龄的差异，与更常见的囊性改变和导管上皮增生一样大。非典型小叶和导管增生、原位癌和隐匿性浸润癌并不常见，并且在种族/民族群体中的发生模式与这些群体中的癌症风险模式相似。
