O'Connell J F, Nesnow S, Slaga T J
University of Texas System Cancer Center, Science Park--Research Division, Smithville 78957.
Cancer Lett. 1987 Nov;37(3):301-10. doi: 10.1016/0304-3835(87)90115-7.
Five doses of either N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 mumol. As complete carcinogens, MNNG from doses of 0.5-5.0 mumol and ENU from doses of 10 mumol-40 mumol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.
在SENCAR皮肤肿瘤发生模型中，对五剂N-甲基-N'-硝基-N-亚硝基胍（MNNG）或乙基亚硝基脲（ENU）作为完全致癌物、肿瘤启动剂和肿瘤促进剂进行了测试。作为肿瘤启动剂，MNNG在所有测试剂量下均诱导出乳头状瘤，而ENU在10-40 μmol时具有活性。作为完全致癌物，0.5-5.0 μmol剂量的MNNG和10 μmol-40 μmol剂量的ENU都是乳头状瘤和癌的有效诱导剂，表明这些试剂作为肿瘤启动剂和肿瘤促进剂均具有活性。
