Slaga T J
Environ Health Perspect. 1986 Sep;68:27-32. doi: 10.1289/ehp.866827.
The SENCAR mouse stock was selectively bred for eight generations for sensitivity to skin tumor induction by the two-stage tumorigenesis protocol using 7,12-dimethylbenz(a)anthracene (DMBA) as the initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as the promoter. The SENCAR mouse was derived by crossing Charles River CD-1 mice with skin-tumor-sensitive mice (STS). The SENCAR mice are much more sensitive to both DMBA tumor initiation and TPA tumor promotion than CD-1, BALB/c, and DBA/2 mice. An even greater difference in the sensitivity to two-stage skin tumorigenesis is apparent between SENCAR and C57BL/6 mice when using DMBA-TPA treatment. However, the SENCAR and C57BL/6 mice have a similar tumor response to DMBA-benzoyl peroxide treatment, suggesting that TPA is not an effective promoter in C57BL/6 mice. The DBA/2 mice respond in a similar manner to the SENCAR mice when using N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-TPA treatment. The SENCAR mouse model provides a good dose-response relationship for many carcinogens used as tumor initiators and for many compounds used as tumor promoter. When compared to other stocks and strains of mice, the SENCAR mouse has one of the largest data bases for carcinogens and promoters.
SENCAR小鼠品系通过两阶段肿瘤发生方案，以7,12-二甲基苯并(a)蒽（DMBA）作为引发剂、12-O-十四酰佛波醇-13-乙酸酯（TPA）作为促癌剂，对皮肤肿瘤诱导的敏感性进行了八代选择性培育。SENCAR小鼠是通过将查尔斯河CD-1小鼠与皮肤肿瘤敏感小鼠（STS）杂交培育而来。SENCAR小鼠对DMBA肿瘤引发和TPA肿瘤促进的敏感性远高于CD-1、BALB/c和DBA/2小鼠。在使用DMBA-TPA处理时，SENCAR小鼠和C57BL/6小鼠对两阶段皮肤肿瘤发生的敏感性差异更为明显。然而，SENCAR小鼠和C57BL/6小鼠对DMBA-过氧化苯甲酰处理的肿瘤反应相似，这表明TPA在C57BL/6小鼠中不是一种有效的促癌剂。在使用N-甲基-N-硝基-N-亚硝基胍（MNNG）-TPA处理时，DBA/2小鼠的反应与SENCAR小鼠相似。SENCAR小鼠模型为许多用作肿瘤引发剂的致癌物和许多用作肿瘤促癌剂的化合物提供了良好的剂量反应关系。与其他小鼠品系和菌株相比，SENCAR小鼠拥有关于致癌物和促癌剂的最大数据库之一。
