小分子抗氧化剂的结构特征及提高潜在生物活性的策略修饰。
Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity.
机构信息
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA.
出版信息
Molecules. 2023 Jan 20;28(3):1057. doi: 10.3390/molecules28031057.
Abstract
This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log , bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.
摘要
本综述调查了被认为是抗氧化剂的各种小分子的主要结构特征，包括天然和合成化合物。还描述了已知小分子抗氧化剂的战略修饰的最新进展。重点是改变主要的物理化学参数，包括 logP、键离解能、电离势等，从而提高抗氧化活性。
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