ISG15/ISGylation 在癌症中的功能作用。
The Functional Roles of ISG15/ISGylation in Cancer.
机构信息
Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Medicinal Chemistry, School of Life Science and Technology, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, China.
Department of Clinical Laboratory, Guizhou Provincial Orthopedic Hospital, No. 206, Sixian Street, Baiyun District, Guiyang 550002, China.
出版信息
Molecules. 2023 Jan 31;28(3):1337. doi: 10.3390/molecules28031337.
The protein ISG15 encoded by interferon-stimulated gene (ISG) 15 is the first identified member of the ubiquitin-like protein family and exists in the form of monomers and conjugated complexes. Like ubiquitin, ISG15 can mediate an ubiquitin-like modification by covalently modifying other proteins, known as ISGylation. There is growing evidence showing that both the free and conjugated ISG15 are involved in multiple key cellular processes, including autophagy, exosome secretion, DNA repair, immune regulation, and cancer occurrence and progression. In this review, we aim to further clarify the function of ISG15 and ISGylation in cancer, demonstrate the important relationship between ISG15/ISGylation and cancer, and emphasize new insights into the different roles of ISG15/ISGylation in cancer progression. This review may contribute to therapeutic intervention in cancer. However, due to the limitations of current research, the regulation of ISG15/ISGylation on cancer progression is not completely clear, thus further comprehensive and sufficient correlation studies are still needed.
干扰素刺激基因 (ISG) 15 编码的蛋白质 ISG15 是第一个被鉴定的泛素样蛋白家族成员，以单体和缀合复合物的形式存在。与泛素一样，ISG15 可以通过共价修饰其他蛋白质来介导泛素样修饰，这种修饰被称为 ISGylation。越来越多的证据表明，游离和缀合的 ISG15 都参与了多个关键的细胞过程，包括自噬、外体分泌、DNA 修复、免疫调节以及癌症的发生和发展。在这篇综述中，我们旨在进一步阐明 ISG15 和 ISGylation 在癌症中的功能，展示 ISG15/ISGylation 与癌症之间的重要关系，并强调 ISG15/ISGylation 在癌症进展中的不同作用的新见解。这篇综述可能有助于癌症的治疗干预。然而，由于目前研究的局限性，ISG15/ISGylation 对癌症进展的调节尚不完全清楚，因此仍需要进行更全面和充分的相关性研究。
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