Wyroba E
Department of Cell Biology, M. Nencki Institute of Experimental Biology, Warsaw, Poland.
Cell Biol Int Rep. 1987 Sep;11(9):657-64. doi: 10.1016/0309-1651(87)90100-7.
Phorbol ester (PMA) exerted a dose- and time- dependent stimulating effect on phagocytosis in axenic Paramecium aurelia. When cells were exposed to 200-800 nM PMA in the presence of latex beads, the phagocytic coefficient was enhanced 2.25 to 3.14 times, during 10 min of continuous treatment and then rapidly declined. A similar effect was observed when the cells were exposed to a forskolin treatment, which resulted in nearly a twofold increase in phagocytic activity after a 10 min pulse. Both PMA and forskolin strongly stimulated phagocytosis (i.e. fivefold and threefold, respectively) in cells in which such activity had been completely inhibited by pre-exposure to the beta-receptor antagonist 1-propranolol.
佛波酯（PMA）对无菌的双小核草履虫的吞噬作用具有剂量和时间依赖性刺激效应。当细胞在乳胶珠存在的情况下暴露于200 - 800 nM的PMA时，在持续处理10分钟期间吞噬系数提高了2.25至3.14倍，然后迅速下降。当细胞接受福斯高林处理时也观察到类似的效应，在10分钟脉冲后吞噬活性增加了近两倍。在预先暴露于β受体拮抗剂1 - 普萘洛尔而使这种活性完全被抑制的细胞中，PMA和福斯高林均强烈刺激吞噬作用（分别为五倍和三倍）。
