Department of Gastroenterology, University Hospital Coventry and Warwickshire, Coventry CV2 2DX, UK.
Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, 1081 Amsterdam, The Netherlands.
Sensors (Basel). 2023 Jan 26;23(3):1377. doi: 10.3390/s23031377.
(1) Background: Colorectal cancer is the second commonest cause of cancer deaths worldwide; recently, volatile organic compounds (VOCs) have been proposed as potential biomarkers of this disease. In this paper, we aim to identify and review the available literature on the influence of mechanical bowel preparation on VOC production and measurement. (2) Methods: A systematic search for studies was carried out for articles relevant to mechanical bowel preparation and its effects on volatile organic compounds. A total of 4 of 1349 papers initially derived from the search were selected. (3) Results: Two studies with a total of 134 patients found no difference in measured breath VOC profiles after bowel preparation; one other study found an increase in breath acetone in 61 patients after bowel preparation, but no other compounds were affected. Finally, the last study showed the alteration of urinary VOC profiles. (4) Conclusions: There is limited data on the effect of bowel preparation on VOC production in the body. As further studies of VOCs are conducted in patients with symptoms of gastrointestinal disease, the quantification of the effect of bowel preparation on their abundance is required.
(1) 背景：结直肠癌是全球第二大常见的癌症死因；最近，挥发性有机化合物（VOCs）被提出作为这种疾病的潜在生物标志物。在本文中，我们旨在确定和综述有关机械肠道准备对 VOC 产生和测量影响的现有文献。
(2) 方法：对与机械肠道准备及其对挥发性有机化合物影响相关的文章进行了系统搜索。从最初的搜索中总共选出了 4 篇论文，其中有 1349 篇。
(3) 结果：两项共有 134 名患者的研究发现肠道准备后测量的呼吸 VOC 图谱没有差异；另一项研究发现 61 名患者在肠道准备后呼吸丙酮增加，但没有其他化合物受到影响。最后，最后一项研究显示尿 VOC 图谱发生了改变。
(4) 结论：关于肠道准备对体内 VOC 产生影响的数据有限。随着对有胃肠道疾病症状的患者的 VOC 进一步研究，需要对肠道准备对其丰度的影响进行量化。
