Department of Biomedical Engineering, City University of Hong Kong, Kowloong Tong, Hong Kong, 999077, P. R. China.
Hong Kong Center for Cerebra-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong, 999077, P. R. China.
Adv Healthc Mater. 2023 Jun;12(15):e2202846. doi: 10.1002/adhm.202202846. Epub 2023 Mar 1.
Intelligent monitoring human physiological information in real time raises the demand for skin-integrated electronics, as which is a flexible format and can be mounted onto the curved human skin for noninvasive healthcare monitoring. The biofluid such as sweat from skin contains abundant biomarkers reflecting body health conditions. Here, a skin-integrated sweat monitor with six biosensors embedded for the detection of NH , Na , glucose, pH, skin impedance, and surface temperature is described, which could decode the information in the fresh sweat generated during exercising. Furthermore, the system also includes an innovative safety warning mechanism, which is based on a miniaturized actuator to provide mechanical stimuli, and coupled with six changeable colors light emitting diodes corresponding to the six biosensors for providing simultaneous safety alarming to users. The self-developed microfluidics system with a hydrophilic surface allows to enhance the sweat collection rate. Meanwhile, microfluidic filters can reduce the interruption of skin debris during biosignal monitoring. These state-of-art biosensors can real-time monitor health related signals with excellent linearity and specificity. The skin-integrated sweat monitor system exhibits a great potential in human healthcare monitoring and medical treatment.
实时智能监测人体生理信息对皮肤集成电子提出了需求,因为它是一种灵活的形式,可以安装在人体曲面上进行非侵入性医疗保健监测。皮肤产生的生物流体(如汗液)中含有丰富的反映身体健康状况的生物标志物。在这里,描述了一种具有嵌入式六个生物传感器的皮肤集成汗液监测器,用于检测 NH 3 、Na + 、葡萄糖、pH 值、皮肤阻抗和表面温度,它可以解码在运动过程中产生的新鲜汗液中的信息。此外,该系统还包括一个创新的安全警告机制,它基于一个微型致动器提供机械刺激,并与六个可更换颜色的发光二极管耦合,对应于六个生物传感器,为用户提供同时的安全报警。具有亲水表面的自开发微流控系统可以提高汗液采集率。同时,微流控过滤器可以减少生物信号监测过程中皮肤碎片的干扰。这些最先进的生物传感器可以实时监测与健康相关的信号,具有优异的线性度和特异性。皮肤集成汗液监测系统在人体健康监测和医疗方面具有巨大的潜力。