镁缺乏的神经学后果：与癫痫的相关性

Neurological consequences of magnesium deficiency: correlations with epilepsy.

Leaver D D, Parkinson G B, Schneider K M

School of Agriculture, La Trobe University, Bundoora, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 May;14(5):361-70. doi: 10.1111/j.1440-1681.1987.tb00985.x.

Abstract

The plasma calcium and magnesium concentrations of sheep have been manipulated by feeding liquid diets with various calcium and magnesium concentrations. 2. When the magnesium status of the diet was low, both plasma calcium and magnesium concentrations declined, but the decline in calcium was much more rapid and extensive when the content of calcium in the diet was also low. This loss of calcium control in magnesium deficiency was attributed to end-organ resistance to parathyroid hormone. 3. Correlation between plasma and CSF calcium and magnesium concentrations indicated that convulsions occurred when CSF magnesium and plasma calcium concentrations declined. 4. The neurological mechanisms likely to be responsible for the induction of these convulsions are discussed and the factors precipitating convulsions in magnesium deficiency and epilepsy are compared.

摘要

通过给绵羊喂食不同钙镁浓度的流质饮食来控制其血浆钙和镁的浓度。2. 当饮食中的镁含量较低时，血浆钙和镁的浓度都会下降，但当饮食中的钙含量也较低时，钙的下降更为迅速和明显。在镁缺乏时钙控制的丧失归因于终末器官对甲状旁腺激素的抵抗。3. 血浆与脑脊液中钙和镁浓度的相关性表明，当脑脊液镁和血浆钙浓度下降时会发生惊厥。4. 讨论了可能导致这些惊厥的神经机制，并比较了镁缺乏和癫痫中引发惊厥的因素。