Zhang Chuan-Hao, Jiang Zhi-Liang, Meng Yuan, Yang Wen-Yan, Zhang Xin-Yu, Zhang Yan-Xia, Khattak Saadullah, Ji Xin-Ying, Wu Dong-Dong
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China; School of Clinical Medicine, Henan University, Kaifeng, Henan 475004, China.
School of Clinical Medicine, Henan University, Kaifeng, Henan 475004, China.
Cell Signal. 2023 Jun;106:110628. doi: 10.1016/j.cellsig.2023.110628. Epub 2023 Feb 10.
Hepatocellular carcinoma (HCC) is the sixth most frequent human cancer and the world's third most significant cause of cancer mortality. HCC treatment has recently improved, but its mortality continues to increase worldwide due to its extremely complicated and heterogeneous genetic abnormalities. After nitric oxide (NO) and carbon monoxide (CO), the third gas signaling molecule discovered is hydrogen sulfide (HS), which has long been thought to be a toxic gas. However, numerous studies have proven that HS plays many pathophysiological roles in mammals. Endogenous or exogenous HS can decrease cell proliferation, promote apoptosis, block cell cycle, invasion and migration through various cellular signaling pathways. This review analyzes and discusses the recent literature on the function and molecular mechanism of HS and HS donors in HCC, so as to provide convenience for the scientific research and clinical application of HS in the treatment of liver cancer.
肝细胞癌（HCC）是人类第六大常见癌症，也是全球第三大重要的癌症死亡原因。HCC的治疗近来有所改善，但由于其极其复杂且异质性的基因异常，其死亡率在全球范围内仍在持续上升。继一氧化氮（NO）和一氧化碳（CO）之后发现的第三种气体信号分子是硫化氢（HS），长期以来它一直被认为是一种有毒气体。然而，大量研究已证明HS在哺乳动物中发挥着多种病理生理作用。内源性或外源性HS可通过各种细胞信号通路减少细胞增殖、促进细胞凋亡、阻断细胞周期、侵袭和迁移。本综述分析并讨论了近期关于HS及HS供体在HCC中的功能和分子机制的文献，以便为HS在肝癌治疗中的科研及临床应用提供便利。
