Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.
Nat Prod Res. 2023 Nov-Dec;37(24):4290-4301. doi: 10.1080/14786419.2023.2177849. Epub 2023 Feb 12.
Lignans are a large category of polyphenolic compounds that have low molecular weight and are widely distributed in the plant kingdom. They have been recognized for their potential antioxidizing and antiproliferative action. One of the most important lignans is cubebin which is abundantly isolated from the leaves and seeds of and . Cubebin possesses numerous biological actions such as antileukemic, trypanocidal, antimycobacterial, analgesic, anti-inflammatory, histamine antagonist, antifungal, and antispasmodic. This review discusses the and pharmacological studies on cubebin related to biochemistry and pharmacological applications and it ensures that it widely shows therapeutic potential. We expect that these therapeutic actions will set a new track in the formation of novel biological agents by the derivatization of cubebin. This review will assuredly fascinate countless researchers to begin further experimentation that might lead to novel agents for the treatment and prevention of diseases.
木脂素是一类具有低分子量和广泛分布于植物界的多酚化合物。它们已被认为具有潜在的抗氧化和抗增殖作用。最重要的木脂素之一是胡椒碱，它大量存在于 和 的叶子和种子中。胡椒碱具有多种生物活性，如抗白血病、杀锥虫、抗分枝杆菌、镇痛、抗炎、组胺拮抗剂、抗真菌和抗痉挛。本文综述了与生物化学和药理学应用相关的 和 对胡椒碱的药理学研究，它确保了胡椒碱具有广泛的治疗潜力。我们期望这些治疗作用将通过胡椒碱的衍生化在新型生物制剂的形成中开辟新的途径。这篇综述无疑将吸引无数研究人员开始进一步的实验，这些实验可能会导致用于治疗和预防疾病的新型药物。
