Vargas Vera Maria Ferrão, da Silva Júnior Flavio Manoel Rodrigues, Silva Pereira Tatiana da, Silva Cristiane Silva da, Coronas Mariana Vieira
Programa de Pós-graduação em Ecologia, Universidade Federal do Rio Grande do Sul (UFRGS). Av. Bento Gonçalves, Porto Alegre, RS, Brazil.
Programa de Pós-graduaç'ão em Ci"ências da Saúde, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
J Toxicol Environ Health B Crit Rev. 2023 Apr 3;26(3):172-199. doi: 10.1080/10937404.2023.2175092. Epub 2023 Feb 12.
This review examined the mutagenicity and genotoxicity associated with exposure to outdoor air pollutants in Brazil. A search was performed on the Web of Science database using a combination of keywords that resulted in 134 articles. After applying exclusion criteria, a total of 75 articles were obtained. The articles were classified into three categories: (1) studies with plants and animals, (2) studies, and (3) human biomonitoring. The investigations were conducted in 11 of 27 Brazilian states with the highest prevalence in the southeast and south regions. Only 5 investigations focused on the effects of burning biomass on the quality of outdoor air. Plants, especially , were the main air pollution biomonitoring tool. When available, a significant association between levels of air pollutants and genetic damage was described. Among the studies, /microsome is the most used test to evaluate mutagenesis of outdoor air in Brazil ( = 26). Human biomonitoring studies were the least frequent category ( = 18). Most of the investigations utilized micronucleus bioassay, in oral mucosa cells ( = 15) and lymphocytes ( = 5), and the comet assay ( = 6). The analysis in this study points to the existence of gaps in genotoxicity studies and our findings indicate that future studies need to address the variety of potential sources of pollution existing in Brazil. In addition to extent of the impacts, consideration should be given to the enormous Brazilian biodiversity, as well as the determination of the role of socioeconomic inequality of the population in the observed outcomes.
本综述考察了巴西室外空气污染物暴露相关的致突变性和遗传毒性。使用关键词组合在科学网数据库进行检索，共得到134篇文章。应用排除标准后，最终获得75篇文章。这些文章分为三类：（1）动植物研究；（2）[此处原文缺失相关内容]研究；（3）人体生物监测。调查在巴西27个州中的11个州进行，东南部和南部地区的调查最为普遍。仅有5项调查聚焦于生物质燃烧对室外空气质量的影响。植物，尤其是[此处原文缺失相关内容]，是主要的空气污染生物监测工具。在有数据可用时，描述了空气污染物水平与遗传损伤之间的显著关联。在[此处原文缺失相关内容]研究中，/微粒体是巴西评估室外空气致突变性最常用的测试方法（n = 26）。人体生物监测研究是最不常见的类别（n = 18）。大多数调查采用微核试验，检测口腔黏膜细胞（n = 15）和淋巴细胞（n = 5），以及彗星试验（n = 6）。本研究分析指出遗传毒性研究存在空白，我们的研究结果表明未来研究需要关注巴西存在的各种潜在污染源。除了影响程度外，还应考虑巴西丰富的生物多样性，以及确定社会经济不平等在观察结果中对人群的作用。
