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脂肪间充质干细胞来源外泌体中高表达的 lncRNA FOXD2-AS1 通过调控 miR-185-5p/ROCK2 轴影响 HaCaT 细胞。

Highly-expressed lncRNA FOXD2-AS1 in adipose mesenchymal stem cell derived exosomes affects HaCaT cells via regulating miR-185-5p/ROCK2 axis.

机构信息

Plastic Surgery of Plastic Surgery Hospital, Weifang Medical University, Weifang, China.

Vascular surgery department, Affiliated Hospital of Weifang Medical College, Weifang, China.

出版信息

Adipocyte. 2023 Dec;12(1):2173513. doi: 10.1080/21623945.2023.2173513.

DOI:10.1080/21623945.2023.2173513
PMID:36775902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9928455/
Abstract

The healing of skin wounds is a highly coordinated multi-step process that occurs after trauma including surgical incisions, thermal burns, and chronic ulcers. In this study, the authors investigated lncRNA FOXD2-AS1 function in adipose mesenchymal exosomes from ADMSCs that were successfully extracted. Highly expressed lncRNA FOXD2-AS1 in ADMSCs-exosomes accelerated HaCaT cell migration and proliferation. LncRNA FOXD2-AS1 negatively targeted miR-185-5p, and miR-185-5p negatively targeted ROCK2. Highly expressed lncRNA FOXD2-AS1 in ADMSCs-exosomes promoted HaCaT cell migration and proliferation via down-regulating miR-185-5p and further up-regulating ROCK2. In conclusion, LncRNA FOXD2-AS1 overexpression in ADMSCs derived exosomes might accelerate HaCaT cell migration and proliferation via modulating the miR-185-5p/ROCK2 axis.

摘要

皮肤伤口的愈合是一个高度协调的多步骤过程，发生在创伤后，包括手术切口、热烧伤和慢性溃疡。在这项研究中，作者研究了 ADMSC 衍生的脂肪间充质细胞外体中 lncRNA FOXD2-AS1 的功能，这些外体已被成功提取。ADMSC-exosomes 中高表达的 lncRNA FOXD2-AS1 可加速 HaCaT 细胞的迁移和增殖。lncRNA FOXD2-AS1 负向靶向 miR-185-5p，而 miR-185-5p 负向靶向 ROCK2。ADMSC-exosomes 中高表达的 lncRNA FOXD2-AS1 通过下调 miR-185-5p 并进一步上调 ROCK2 促进 HaCaT 细胞的迁移和增殖。总之，ADMSC 衍生的外体中 lncRNA FOXD2-AS1 的过表达可能通过调节 miR-185-5p/ROCK2 轴加速 HaCaT 细胞的迁移和增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/d64ec7aebb0c/KADI_A_2173513_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/f014a66c7e82/KADI_A_2173513_F0001_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/894181f6f10c/KADI_A_2173513_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/0bf454934278/KADI_A_2173513_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/7e5268979d1f/KADI_A_2173513_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/d64ec7aebb0c/KADI_A_2173513_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/f014a66c7e82/KADI_A_2173513_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/a52429bdddd3/KADI_A_2173513_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/520a3c4fd38a/KADI_A_2173513_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/894181f6f10c/KADI_A_2173513_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/0bf454934278/KADI_A_2173513_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/7e5268979d1f/KADI_A_2173513_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f50/9928455/d64ec7aebb0c/KADI_A_2173513_F0007_OC.jpg

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