Coiffier E, Paris R, Lecerf J
Laboratoire de Physiologie Animale et de la Nutrition, U.A. C.N.R.S. 273, Faculté des Sciences Mirande, Université de Dijon, France.
Comp Biochem Physiol B. 1987;88(1):187-92. doi: 10.1016/0305-0491(87)90099-x.
The effects of saturated and polyunsaturated dietary fat on the lipolytic activity of post-heparin plasma, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) were studied in the rat. The lipolytic activity was studied from 0 to 60 min using labelled chylomicrons as the substrate. Triacylglycerol hydrolysis rate was higher for the plasma of rats fed high fat diets (14% fat by weight). Chylomicrons of rats fed saturated or unsaturated fats were hydrolyzed at the same rate within the first 15 min but afterwards hydrolysis of chylomicrons of rats fed saturated fat was slower. The activities of LPL and HTGL were increased by high fat diets. Unsaturated fat increased more LPL activity than saturated fat conversely, HTGL activity was enhanced more by saturated fat than by unsaturated fat.
在大鼠中研究了饱和与多不饱和膳食脂肪对肝素化后血浆的脂解活性、脂蛋白脂肪酶（LPL）和肝甘油三酯脂肪酶（HTGL）的影响。使用标记的乳糜微粒作为底物，在0至60分钟内研究脂解活性。喂食高脂肪饮食（按重量计14%脂肪）的大鼠血浆中三酰甘油水解速率更高。喂食饱和或不饱和脂肪的大鼠的乳糜微粒在最初15分钟内以相同速率水解，但之后喂食饱和脂肪的大鼠的乳糜微粒水解较慢。高脂肪饮食会增加LPL和HTGL的活性。不饱和脂肪比饱和脂肪更能增加LPL活性，相反，饱和脂肪比不饱和脂肪更能增强HTGL活性。
