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无毛小鼠对二硝基氟苯的脱敏作用。

Desensitization to DNFB in hairless mice.

作者信息

Copeman M C

机构信息

Clinical Immunology Research Centre, University of Sydney, New South Wales, Australia.

出版信息

Contact Dermatitis. 1987 Sep;17(3):146-8. doi: 10.1111/j.1600-0536.1987.tb02694.x.

DOI:10.1111/j.1600-0536.1987.tb02694.x
PMID:3677657
Abstract

Naive hairless mice may be rendered partly tolerant to dinitrofluorobenzene (DNFB) by painting DNFB on skin irradiated with 30 mJ.cm-2 ultraviolet B light (UVB) over 4 days. However, DNFB-sensitized hairless mice show no decrease in sensitivity when repainted with DNFB on skin irradiated with the same dose of UVB. Hence, established hypersensitivity appears not to be reduced by this method of inducing tolerance in naive mice.

摘要

通过在4天内对用30 mJ.cm-2中波紫外线（UVB）照射过的皮肤涂抹二硝基氟苯（DNFB），可使未接触过抗原的无毛小鼠对DNFB产生部分耐受性。然而，当对用相同剂量UVB照射过的皮肤再次涂抹DNFB时，已对DNFB致敏的无毛小鼠的敏感性并未降低。因此，这种在未接触过抗原的小鼠中诱导耐受性的方法似乎无法减轻已建立的超敏反应。

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