Wang Yanan, Zhao Hanyu, Huang Lijie, Chen Guangxue, Wei Zhehao, Mo Qi, Li Yishan, Wang Xiyue, Huang Chongxing, Chen Qifeng
Guangxi University, Nanning, 530004 China.
South China University of Technology, Guangzhou, 510000 China.
Cellulose (Lond). 2023;30(5):3073-3082. doi: 10.1007/s10570-023-05070-6. Epub 2023 Feb 3.
Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO as a model drug, and a sustained-ClO-gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and β-cyclodextrin (βCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4-35 ℃ and released ClO gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer-Peppas model, and an excellent fit was obtained. This sustained-ClO-gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels.
The online version contains supplementary material available at 10.1007/s10570-023-05070-6.
由于具有独特的物理化学和生物学特性，以及能够与多种材料结合以实现生物相容性和亲水性，羧甲基纤维素（CMC）是一种作为载体的极佳选择。将二氧化氯（ClO）负载到可生物降解载体中，因其良好的消毒性能和高安全系数而备受关注。因此，在本研究中，我们以ClO为模型药物，通过简单且温和的交联策略，利用羧甲基纤维素（CMC）、聚乙烯醇（PVA）和β-环糊精（βCD）等可降解材料制备了一种二氧化氯气体缓释凝胶。值得注意的是，该凝胶在4 - 35℃的宽温度范围内具有缓释性能，并且能有效释放ClO气体超过30天。此外，基于药物在缓释过程中的不完全释放提出了一个损失因子，以实现与气体扩散过程的良好拟合。基于Korsmeyer-Peppas模型设计了一种新的扩散模型，并获得了极佳的拟合效果。这种二氧化氯气体缓释凝胶为开发用于太空的持续消毒剂释放剂提供了理论和技术指导，并为骨架溶性水凝胶的缓释模型提供了新的见解。
在线版本包含可在10.1007/s10570-023-05070-6获取的补充材料。
