Berman John P, Kaboudian Abouzar, Uzelac Ilija, Iravanian Shahriar, Iles Tinen, Iaizzo Paul A, Lim Hyunkyung, Smolka Scott, Glimm James, Cherry Elizabeth M, Fenton Flavio H
School of Physics, Georgia Institute of Technology, Atlanta, GA, USA.
Division of Cardiology, Emory University, Atlanta, GA, USA.
Comput Cardiol (2010). 2021 Sep;48. doi: 10.23919/cinc53138.2021.9662948. Epub 2022 Jan 10.
Understanding cardiac arrhythmic mechanisms and developing new strategies to control and terminate them using computer simulations requires realistic physiological cell models with anatomically accurate heart structures. Furthermore, numerical simulations must be fast enough to study and validate model and structure parameters. Here, we present an interactive parallel approach for solving detailed cell dynamics in high-resolution human heart structures with a local PC's GPU. In vitro human heart MRI scans were manually segmented to produce 3D structures with anatomically realistic electrophysiology. The Abubu.js library was used to create an interactive code to solve the OVVR human ventricular cell model and the FDA extension of the model in the human MRI heart structures, allowing the simulation of reentrant waves and investigation of their dynamics in real time. Interactive simulations of a physiological cell model in a detailed anatomical human heart reveals propagation of waves through the fine structures of the trabeculae and pectinate muscle that can perpetuate arrhythmias, thereby giving new insights into effects that may need to be considered when planning ablation and other defibrillation methods.
要通过计算机模拟来理解心律失常机制并开发控制和终止心律失常的新策略，需要具有解剖学精确心脏结构的逼真生理细胞模型。此外，数值模拟必须足够快，以便研究和验证模型及结构参数。在此，我们提出一种交互式并行方法，用于利用本地个人计算机的图形处理器（GPU）在高分辨率人类心脏结构中求解详细的细胞动力学。对体外人类心脏磁共振成像（MRI）扫描进行手动分割，以生成具有解剖学逼真电生理学的三维结构。使用Abubu.js库创建交互式代码，以求解OVVR人类心室细胞模型及其在人类MRI心脏结构中的FDA扩展模型，从而能够实时模拟折返波并研究其动力学。在详细的解剖学人类心脏中对生理细胞模型进行交互式模拟，揭示了波通过小梁和梳状肌的精细结构传播的情况，这种传播可能使心律失常持续存在，从而为规划消融和其他除颤方法时可能需要考虑的影响提供了新的见解。
